Furanones: Quorum-Sensing Inhibitors
Etiquetas:
Furanones,
Quorum Quenching,
quorum sensing
Researches
has shown the ability of furanones for inhibiting biofilm formation by blocking
the signaling system between bacteria or "Quorum- Sensing".
These
complex communities called biofilms, contribute to the strength and persistence
of many pathogenic bacteria in food processing facilities, contributing to
foodborne Illness.
The control
and eradication of biofilms require different strategies, including periodic
processes of cleaning and sanitizing with chemicals of high efficiency.
To form biofilms,
bacteria communicate cell to cell
through signaling molecules, a mechanism known as "Quorum - Sensing" (QS). This
chemical signal allow them to live
together and protected by a sticky matrix and adherent, evading the action of
sanitizers and other chemicals solutions.
Scientists
are working on the development of new disinfectants, whose mechanism of action
is blocking the QS. This interference of
communication, prevents bacteria are added and thus could prevent the
development of biofilm.
For this purpose,
has been testing the action of substances called furanones, whose molecule were
originally isolated from a type of algae called Delisea pulchra. Using
synthetic variants of this substance,
have ability to block the
communication between bacteria and to inhibit complex formation of Salmonella
enterica biofilm.
Currently
also being tested sanitizers with addition of furanones to enhance antibiofilm
activity, due to their antagonistic properties.
Research on
initial biofilm formation of Streptocuccus mutans, principal responsible for the formation of dental
plaque and tooth decay, have ratified the inhibitory effect of synthetic
furanones.
The
discovery of these new molecules which prevent plaque formation by interfering
with the QS, opens a new field of food science research and dental care, which
could lead to common solutions, "the future of the toothpaste and
disinfectant ideal for combating biofilm. "
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